Selected Publications
Nature, 577(7792):676-681, 2020
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.
Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Goncalves W, Shwartz Y, Fast EV, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu Y.
Cell 180, 33–49, 2020
Gut-innervating nociceptor neurons regulate Peyer's patch microfold cells and SFB levels to mediate Salmonella host defense.
Lai NY, Musser MA*, Pinho-Ribeiro FA*, Baral P*, Jacobson A*, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM
* contributed equally
Nature Reviews Immunology, 19(7):433-447, 2019
Pain and immunity: implications for host defence
*Baral P, Udit S, Chiu IM.
*Selected for journal cover: Touching a Nerve. Nature Reviews Immunology. 2019, July issue
Blood, 133(12):1335-1345, 2019
CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by Streptococcus pneumoniae serotype 3.
Paudel S, Baral P, Ghimire L, Bergeron S, Jin L, DeCorte JA, Le JT, Cai S, Jeyaseelan S.
Mucosal Immunology,12(1):247-257, 2019
NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during Gram-positive pneumonia.
Paudel S, Ghimire L, Jin L, Baral P, Cai S, Jeyaseelan S.
Nature Medicine, (4):417-426, 2018
Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.
Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM.
Highlighted in:
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Neuroimmunology: No pain, all gain. Nature Reviews Immunology. Mar 2018.
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Harvard Medicine: https://hms.harvard.edu/magazine/cost-conflict/research-hms
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Science Daily: https://www.sciencedaily.com/releases/2018/03/180305111520.htm
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CCTV: https://tv.cctv.com/2018/04/23/VIDErFHRlOGEHgQKOIsVcz1V180423.shtml
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Recommendations by Daniel Mucida and Charles Parkos on Faculty Opinions (formerly F1000Prime)
Nature Communications, 9(1):37, 2018
Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.
Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM.
Nature, 549(7672):351-356, 2017
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK.
Cell Host and Microbe, 19(6):755-9, 2016
Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?
Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM.
American Journal of Respiratory and Critical Care Medicine, 190(7):722-32, 2014
Divergent functions of Toll-like receptors during bacterial lung infections.
Baral P, Batra S, Zemans RL, Downey GP, Jeyaseelan S.
Infection and Immunity, 80(12):4223M31, 2012
Involvement of signal regulatory protein, a negative regulator of Toll-like receptor signaling, in impairing MyD88-independent pathway and intracellular killing of Burkholderia pseudomallei-infected mouse macrophages.
Baral P, Utaisincharoen P.
For a complete list of publications visit PubMed or Google Scholar